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The company also said that the treatment showed clinically meaningful benefits across key cardiovascular risk factors, which include non-HDL cholesterol, systolic blood pressure and triglycerides

Exendin-4-stimulated GLP-1R triggers VAPB-localised cAMP generation and PKA activity at the outer mitochondrial membrane As stated above, besides VAPB, our interactome analysis highlighted several factors enriched for their association with active GLP-1R localised at the ER, mitochondria and/or ERMCSs, a location where VAPB plays a prominent organising role 17 , suggesting that ERMCSs could be a potential hub for endosomal GLP-1R signalling

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