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It does so by acting as an agonist a substance that mimics the naturally occurring hormone by attaching to the same cell receptors in the brain and producing a similar or enhanced response in the body, including improved insulin release, lower appetite and slow digestion

doi:10.1016/j.ygyno.2018.07.007 Li Y, Xu X, Asif H, et al

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Moreover, as hypothyroidism can cause weight gain, semaglutides efficacy in weight reduction could be particularly beneficial in hypothyroid patients struggling with obesity or overweight