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R COMT Val158Met COMT Val158Met (rs4680) is one of the most studied Phase II genetic variants

For instance, glutathione requires other cofactors and processes along the methylation pathway and must pass through the liver to be activated for use

Similar finding was reported by Nassar and collaborators who studied twenty-one patients on KDT, and their results showed more than 50% reduction in their seizures 23

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Motor functioning was evaluated starting at 2 weeks post-surgery and testing was conducted on a biweekly basis using a walking track analysis where the rats were made to walk in a confined walkway lined with white paper and led into a dark shelter