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This action helps reach optimal results with careful monitoring
Metformin is not recommended when eGFR is consistently less than 30 mL/min/1.73 m 2 , and in LEADER, SUSTAIN 6 and PIONEER 6, some of those who were not taking metformin had lower eGFRs
Typical monitoring might involve checking thyroid function every 3 to 6 months during active weight loss, then returning to standard annual monitoring once weight stabilizes
Its effectiveness has been compared to stronger treatments, such as hydroquinone, and has shown similar efficacy with fewer adverse effects
For women specifically, the way the growth hormone axis shifts after 35 changes the conversation, which our team covers in detail in our guide to why the growth hormone axis changes for women after 35 and how a supervised CJC-1295/Ipamorelin protocol addresses it
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