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10.1016/j.atherosclerosis.2010.04.024 Atherosclerosis 23 CampbellJ

The slower pace often leads to more sustainable results because the medication supports ongoing appetite regulation

This helps maintain: Daily energy levels Reduced fatigue Better physical performance Healthy metabolism Supports Cardiovascular Health L-Arginine promotes healthy nitric oxide production, which supports normal blood circulation

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The NDA submission was partly based on topline results from the ongoing single location BHV4157-206-RWE study (NCT06529146), in which troriluzole 200 mg administered orally once daily led to a 5070% slower rate of decline from baseline in the functional Scale for the Assessment and Rating of Ataxia (f-SARA) in all SCA genotypes at 3 years compared to an external control arm. Data from the BHV4157-206 study (NCT03701399) also demonstrated disease stabilization in the SCA3 genotype and a reduction in falls in all SCA genotypes compared to placebo over 48 weeks. If approved, troriluzole will be the first and only medication indicated for the treatment of SCA