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6 Clinical evidence: from epidemiological promise to trial disappointment The progression of semaglutide from a metabolic medication to a prospective neurotherapeutic agent has been marked by a notable and challenging discrepancy between observational data and randomized controlled trial (RCTs) outcomes

Initially, the US Food and Drug Administration approved Wegovy, the brand name for a GLP-1-based medicine called semaglutide, for chronic weight management in June 2021

Instant coffee drinkers trended the opposite way, ageing faster than their real age