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Why does glucagon agonism of retatrutide cause dysesthesia in 20,9% of subjects

If 0.25 mg makes you nauseous, they can officially prescribe 0.1 mg, something a standard pharmacy cannot do

Patients in the clinical trials, who all have diabetes and/or obesity, also had fewer complaints about nausea and diarrhea

While it should never be viewed as a substitute for a nutrient-dense diet and a rigorous training program, it is an incredibly effective tool

The study was designed to have 80% power to detect a treatment effect between the clusters, assuming that the true difference in treatment effect between clusters was 3 mmol mol 1 (which would be clinically relevant given previous reports on the association between HbA1c and vascular complications 31 )