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This effect is particularly noticeable during the initial weeks of treatment or following dose escalation, as the body adjusts to the medication's influence on gastrointestinal motility

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Primary weight loss failure after Roux-en-Y gastric bypass is characterized by impaired gut-hormone mediated regulation of food intake

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A 2025 study of 200 adults combining GLP-1 medications with resistance training education and individualized protein intake (generally above 0.36 g/lb) showed participants lost approximately 13% of body weight but only 3% of muscle mass after six months