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ROS are responsible for the irreversible oxidation of essential cellular components such as proteins and nucleic acids

WangY , Kole HK, Montrose-Rafizadeh C, Perfetti R, Bernier M, Egan JM

doi: 10.1007/s00210-014-1008-y 118 UnaySBilginMD

As the activation of both JNK and caspase-3 contributed to TNF-induced cell death with NF-B inhibition, we examined the effects of HFD consumption on the hepatic activation status of JNK and caspase-3 cleavage