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TGR inhibitors 1 - 6 were found to have higher potency against S

Despite this shared mechanism, the two receptors exhibit distinct expression patterns and physiological roles that are genuinely complementary: When both axes are activated concurrently, the cAMP response in pancreatic -cells exceeds that of either agonist alone, indicating synergistic rather than merely additive intracellular signaling

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11,34,35 Abnormal functioning of the autonomic nervous system, a key regulator of the stress response, is thought to be an important underlying mechanism in fibromyalgia