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Abstract Reduced brain-derived neurotrophic factor (BDNF) may underlie age-related synaptic loss, in turn contributing to cerebral atrophy, cognitive decline, and increased risk for psychiatric disorders

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Moreover, our present data with retatrutide are in line with previous reports on contractile effects in the rat atrium

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White concluded her remarks by saying, The findings add to a growing body of evidence suggesting GLP-1 receptor agonists may have broader neurologic and anti-inflammatory effects beyond weight loss alone. While more research is needed before GLP-1s can be recommended as a migraine therapy, this study offers the promise that semaglutide might also ease the burden of migraine for many females.

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Key Takeaways Retatrutide remains investigational and is not routine clinical treatment

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& Cohen, N

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