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It acts as a substrate linker for the interaction of Cullin 3 (CUL3)-dependent E3 ubiquitin ligase complex [119], with NRF2 leading to continuous ubiquitination and proteasomal degradation of NRF2 [120], thus representing the main negative regulator of NRF2 activity
Possible mechanisms of the reduction of ammonia levels by L-carnitine are (1) increased production of ATP, which is essential for the conversion of ammonia to urea, and (2) stimulation of the urea cycle via production of N-acetylglutamate
It is well known that eukaryotic genomes are transcribed in both sense and antisense directions, producing abundant levels of noncoding RNAs (107)
10.3892/ijmm.2012.1042 Int