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Freezing can alter the protein structure of the medication, making it less effective
In the first study, fasted healthy mice were submitted to an intraperitoneal glucose tolerance test (IPGTT) 5 min after dosing 1 and 14 in order to validate the activity of the reference peptide 1
P = NS)
8.5 Geriatric Use In the pool of glycemic control trials, 1,229 (30%) RYBELSUS-treated patients were 65 years of age and over and 199 (5%) RYBELSUS-treated patients were 75 years of age and over [see Clinical Studies (14)]
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