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The most common adverse reaction with HUMIRA was injection site reactions

They also appear to have an effect on food noise, or the constant, intrusive thoughts about food that are disruptive to daily life

Furthermore, the allocation of limited supplies often prioritizes newer prescriptions over existing ones, leaving long-term users without consistent access

There are also three peptide YY (PYY) agonists and two GLP-1/PYY dual agonists currently in phase 1 or phase 2 studies

As of this writing (July 2024), we are not aware of robust head-to-head RCTs comparing GLP-1 medications outcomes to outcomes with other forms of weight loss intervention on validly-measured SMM, strength, or function