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[1] [4] While this appetite suppression facilitates substantial weight loss, it also creates a clinical challenge: ensuring adequate protein intake to preserve lean body mass

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GLP-1s Direct Biological Impact in the Brain Beyond their systemic metabolic effects, GLP-1 medications exert direct biological actions in the brain through widespread expression of incretin (GLP-1) receptors in regions critical for cognition, including the hippocampus, prefrontal cortex, and hypothalamus [14]