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While tirzepatide's primary therapeutic targets relate to metabolic function, receptor activation in these brain areas could potentially influence mood pathways, though human evidence for direct effects remains limited and inconclusive

"Individual patient eligibility for drug therapies available through Sesame are determined by the assessment of appropriateness of each therapy by the Sesame-listed provider, and are subject to availability," according to the company

76 VSG involves resection of the majority of the stomach to create a slender tubular gastric pouch, thereby reducing gastric capacity and limiting food intake to achieve weight loss

SGLT2i use was associated with a significantly increased risk of DKA (RR 2.08 [95% CI 1.05, 4.12] p =0.0309)