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Two-hour bile samples were collected from another group of mice via a catheter (SAI-infusion, IL, United States) fixed in the extrahepatic bile duct for the first 2 hours after the administration of the cocktail ( 2.7 Quantification of drug cocktail and metabolites Sample workup of plasma samples and determination with LC-MS/MS was performed as described previously ( 2.8 Measurement of bile flow rate To measure the rate of bile flow in cirrhotic and control mice, a mouse catheter (SAI-infusion, IL, United States) was placed in the extrahepatic bile duct of 12-month CCl 4 - or oil-treated mice (day 6 after the last injection), and the outflowing bile was collected as previously described ( 2.9 Bioinformatics of transcriptomics data sets The chronic CCl 4 mouse model has been published in All bioinformatics-related analyses were performed in R (version 4.2.1)

Cada cpsula aporta 250 mg de GSH de alta pureza, combinacin de tripptido compuesta por L-Cistena, cido L-Glutmico y glicina

Such measures remove the need for long-term administration of cyanocobalamin