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Co-agonism showed, on murine models, the capability to improve insulin secretion and sensitivity in a weight-dependent and weight-independent manner, probably through its action on nutrient metabolism (49, 50), preventing their accumulation and thus making these organs actively involved in metabolism with an improvement in insulin sensitivity and WL, yielding long-lasting effects

When compared to control thresholds, which have a baseline of 1.31mIU/l or 0.4ng/ml, this increase might represent more than a 60-fold enhancement

Any suggestion that such a combination is supported by the existing literature should be treated with caution

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