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They are also not recommended in individuals with certain conditions such as inflammatory bowel disease, pancreatitis, personal or family history of medullary thyroid cancer or multiple endocrine neoplasia

The specific requirements vary by state and by profession

Athletes commonly use 40-50 mcg daily for men and 20 mcg for women, injected before or after workouts

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This deliberate tuning of receptor affinity allows the compound to produce balanced activation across all three pathways without overwhelming any single one