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Subsequent stratification by report frequency and reporting odds ratio (ROR) identified the top 25 gender-specific PTs, which were subsequently visualized through volcano plot analysis (Fig

Third, efforts were made to minimize potential bias due to heterogenous medication adherence in real-world patients, namely (1) the study cohort was restricted to include only stable users of study drugs to eliminate the potential confounding effect from the short-term use or non-adherence of study drugs and (2) sensitivity analyses were performed based on the AT scenario to estimate treatment effectiveness, with patients who discontinued or switched study drugs censored to corroborate our base-case analysis results based on the ITT scenario

In most circumstances, these documents have been created to complement clinical practice guidelines and to inform clinicians about areas where evidence is new and evolving or where sufficient data is more limited

It is a pathologic condition deserving particular attention due to its severity and diffusion especially in Western countries for its alarming impact on health and care costs [1,2,3]

Improved liver markers indicate reduced inflammation, lower fat content, and better overall liver function