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GIP is another type of incretin hormone
SGLT2-i induced natriuresis and glomerular hemodynamics changes resemble, even partially, those observed with sacubitril/valsartan, a first in-class angiotensin receptor neprilysin inhibitor (ARNi)
They are not considered to be interchangeable
The agency restated fundamental law: You must conduct process validation you are not excused just because an AI did not identify the requirement. The warning letter then emphasized that if Purolea intends to resume manufacturing (it had already ceased production) any AI output must be reviewed and cleared by an authorized human in the Quality Unit ( [39] )
Ito H et al
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