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The issue with these weight-loss drugs is that, despite their success in shedding weight while patients are taking them, studies report significant weight regain when people come off them
Retrieved from Mehta, R
GHS-R is a constitutively active G protein-coupled receptor (GPCR), which is able to initiate signaling activation in the absence of ligand ghrelin 26, 27
In general, oral semaglutide for weight management is appropriate for adults with a BMI of 30 or above (obesity), or a BMI of 27 or above alongside a weight-related health condition such as type 2 diabetes, high blood pressure, or elevated cholesterol
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