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Gut microbes convert primary bile acids to secondary bile acids, which influence various neurological outcomes [2]
While metformin has been a cornerstone diabetes medication for decades, GLP-1 receptor agonists like semaglutide (the active ingredient in Ozempic) work through entirely separate physiological systems
These SCFAs help to activate receptors on L-cells that line the gut, triggering the release of GLP-1
The dual GLP-1/GIP mechanism proved more potent than single-pathway GLP-1 therapies alone, making tirzepatide a preferred choice for patients seeking maximum appetite suppression and metabolic benefit
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