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In human endothelial cells and animal models, empagliflozin enhances mitochondrial membrane potential, reduces mtROS production, and upregulates antioxidant enzymes (e.g., SOD2, catalase) via AMPK and Nrf2 activation

As a result, treatments targeting only apoptosis have been shown to be only partially effective [21]

Research Priorities and the Translational Opportunity Despite limited clinical evidence, the biologic plausibility and widespread exposure base represent a translational opportunity for orthopaedics

Long-term use of Glutathione has been associated with lower zinc levels in some individuals, so monitoring zinc levels may be advisable with extended use

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