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Current trial protocols use once-daily dosing, but the improved bioavailability could theoretically support less frequent administration in the future

Compared with those homozygous for the active GSTM1 allele (2 copies), those heterozygous (1 copy) or homozygous (0 copies) for the GSTM1(0 ) allele have a significantly increased risks of the composite outcome of reduction in glomerular filtration rate (GFR) or dialysis and the composite outcome of reduction in GFR, dialysis, or death 30 (Table 1)

A sensitivity analysis excluding the ITCA trial yielded consistent results (HR (95%CI): 0.86 (0.800.94)

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They need to use consistent functional outcome measures, such as timed up-and-go tests or chair-stand tests