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An already-elevated baseline IGF-1 is a reason not to push the axis higher, and because GH antagonizes insulin, glucose handling deserves attention in patients with diabetes or prediabetes
2014 Dec;171(24):5696-707
Jones HM, Chen Y, Gibson C, et al
In light of these findings, we postulated that long-term fluctuating glycemia, especially after extra carbohydrate intake, continuously and waveringly generates extra ROS, which in turn damages the pancreatic -cells
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