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doi: 10.1136/THX.2003.012146 129 DAmatoG
In rat models of inflammatory bowel disease, the peptide reduced inflammation, promoted mucosal healing, and improved intestinal barrier function
In a 26-week study, orforglipron demonstrated a significant dose-dependent effect on weight loss, with weight reduction ranging from 8.6% to 12.6% across various dosages, compared to only 2.0% in the placebo group
10.1016/j.molcel.2018.10.042 40 GascnS.MurenuE.MasserdottiG.OrtegaF.RussoG
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Similarly, GWS has been associated with elevated oxidative stress (Shetty et al., 2017) with melatonin being shown to improve brain function in the GWS model, through modulation of oxidative stress (Madhu et al., 2021)
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