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Constipation is another common issue, reported in 21-25% of retatrutide users and a significant percentage of cagrilintide users

Kumar TR, Wiseman AL, Kala G, Kala SV, Matzuk MM, Lieberman MW: Reproductive defects in gamma-glutamyl transpeptidase-deficient mice

The authors also wrote that their analysis of progression to wet AMD may have been underpowered due to the substantially smaller cohort size