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GLP-1 receptor agonists demonstrate modest but clinically meaningful effects on lipid profiles, though cholesterol reduction is not their primary therapeutic indication

GSH serves as a cofactor for several detoxification enzyme (e.g., glutathione peroxidase: GPx), assists in the transport of amino acids through the plasma membrane, and is able to regenerate the C- and E-vitamins and direct scavenger of OH and singlet oxygen (42, 47)

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Estrogen-driven collagen decline accelerates during perimenopause, and substrate is typically already more depleted at baseline