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The unlabelled peptide is used alongside it as a full-agonist reference point in cAMP accumulation assays, since all five melanocortin receptors are class A G-protein-coupled receptors signalling principally through Gs and adenylyl cyclase

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Professor Jastreboffs research contributions include: Principal investigator for GLP3 phase 2 obesity trial demonstrating 24.2% weight loss Leadership in clinical research examining triple hormone receptor agonists Extensive investigations of incretin-based therapies for obesity and metabolic disease Pioneering work on combination approaches to weight management Studies examining neurobiological mechanisms underlying obesity pharmacotherapy Her work has helped establish GLP3 as one of the most promising next-generation obesity treatments in clinical development, contributing to the scientific foundation for multi-pathway metabolic interventions

2020 Jan;18(1):57-69