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The patches sit at around 3.4 stars on Trustpilot, with reviews split between people who report feeling less hungry and people who saw no effect after a month or more of consistent use

Glycaemic outcomes were equally striking: 7782% of participants on retatrutide achieved euglycaemia (HbA1c 6.5%), and between 5763% achieved body weight reductions of 15% or more

Participants in the SGLT2i group demonstrated improvement in renal function with an increase in mean eGFR over the 5-year follow-up period (+3.5 ml/min per 1.73 m 2 ), compared with an overall reduction in eGFR in the GLP-1 RA cohort (7.2 ml/min per 1.73 m 2 )

Robust clinical evidence supports the inclusion of agents such as semaglutide and liraglutide for reducing HbA1c levels, achieving substantial weight loss, and mitigating complications associated with T2DM and obesity (16)(39)