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The mechanisms underlying these effects involve mesenchymal stem cell proliferation and directed migration to injury sites, periosteum reactivation initiating new bone formation at attachment points, nitric oxide pathway modulation enhancing vascular tone and blood supply, and cytoprotective effects reducing tissue necrosis during the critical early inflammatory phase
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VEGFR2 may be involved in endothelial cell development, proliferation, and lifespan (5)
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Sunscreen will also be critical in keeping melasma from darkening
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