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According to the SmPC, semaglutide has a half-life of approximately one week, and steady-state plasma concentrations are reached after 45 weeks of once-weekly administration
In fact, over the past several years, plan spending on GLP-1s relative to other medications has increased significantly since 2023
Their half-lives are 13 hours (LIRA) and 7 days (SEMA), allowing for daily and weekly subcutaneous administration, respectively, thanks to the structural modifications introduced.5,10 Effects on obesity and glycaemic control Both LIRA 3 mg and SEMA 2.4 mg have demonstrated a strong appetite-suppressing and satiety-promoting effect, as well as a delaying effect on gastric emptying.11,12 The SCALE programme highlighted the efficacy of LIRA 3 mg in reducing body weight and waist circumference13 and confirmed a reduction in HbA1c levels in individuals with diabetes, along with a decreased progression from prediabetes to diabetes after three years of treatment14 (Table 1)
Switching from semaglutide to tirzepatide requires a dose conversion to avoid either under-treatment or excessive initial dosing
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