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They also induce satiety, reducing appetite and calorie intake, thus enabling weight loss via a direct effect on the hypothalamus (Nauck and Meier, 2016)
95% CI, 0.63-3.12)
Your provider should adjust based on symptom response and repeat biomarker testing
Metformin typically reduces A1C by 1.0-1.5% and does not cause hypoglycemia when used alone
GLP-1s, however, may also exert direct hormonal effects as GLP-1 receptors can be found across the hypothalamus-pituitary-ovarian (HPO) axis and influence gonadotropin release and follicle development
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