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In conclusion, metabolic surgery was significantly associated with a 60% lower risk of progression of kidney damage and a 44% lower risk of kidney failure or death compared to GLP-1RA in patients with type 2 diabetes, obesity, and CKD

The FDA has not approved compounded versions of these drugs, and such products may carry safety, quality, and effectiveness risks due to variations in formulation, incorrect ingredients, improper storage, or inaccurate dosing

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This suggests that there might be different lipid metabolic pathways in the two subtypes of HF, and inhibiting myocardial energy deficiency, by restoring ATP-dependent LV relaxation and contraction, might cause beneficial effects in HFpEF [7]