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The body is adjusting to slower digestion, and this shift can cause gastrointestinal discomfort
GLP-1 blocks that dopamine peak. Grigson started studying this phenomenon in rodents in 2018 and found that those addicted to heroin and given a GLP-1 agonist reduced their heroin taking, compared with the ones that were not given a GLP-1 agonist
Ismaiel A, Scarlata GGM, Boitos I, et al
Because it is not a peptide: - It survives the stomach without requiring SNAC absorption technology - It does not need to be taken on an empty stomach - It has higher and more consistent oral bioavailability - It is simpler and cheaper to manufacture at scale The ACHIEVE Phase 3 clinical program includes four trials evaluating orforglipron for obesity and type 2 diabetes, with results expected throughout 2026
About Kyowa Hakko Europe & Kyowa Hakko Bio Italia Kyowa Hakko Europe and Kyowa Hakko Bio Italia are the Central-North and South European sales office for Kyowa Hakko Bio Co
