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Material is held under temperature-controlled conditions in our domestic facility and released against HPLC-MS data sheets to keep batch-to-batch variability tightly bounded

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Binding of RGD motif-containing ligand mimetic compounds to site I is mechanically coupled to tertiary changes in the A domain, involving inward movement of the N-terminal 1 helix toward the MIDAS, forcing reorganization of the loop between the C-terminal F strand and 7 helix, a one-turn displacement of helix 7 and a hybrid domain swing out 42

2011 Mar;2(2):78-88