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Targeting metabolic adaptive responses induced by glucose starvation inhibits cell proliferation and enhances cell death in osimertinib-resistant non-small cell lung cancer (Nsclc) cell lines

After 2, 4, and 6 days of culture, the cell number in the PDL9 group was significantly lower than that in the PDL3 group (Figure 1C), which indicated that the proliferative ability of senescent chondrocytes was significantly decreased

These include apoptosis, autophagy, pyroptosis, and ferroptosis

Following synthesis, the crude peptide undergoes purification using reverse-phase high-performance liquid chromatography (RP-HPLC) to remove synthesis-related impurities and isolate the target compound

Moreover, in vitro stimulation of the intestinal epithelial Caco-2 cell line with fecal supernatants (FSN) of mice induced for CIA, showing elevated serum zonulin levels, effectively suppressed ZO-1 protein expression (Fig