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In the earlier Phase 2 trial, the highest dose tested (45 mg) produced 14.7% weight loss at 36 weeks, suggesting that longer treatment and dose optimization may yield further improvements

Promotion of muscle cell differentiation and satellite cell support: IGF signaling is involved in the activation and differentiation of satellite cells, which are precursor cells responsible for muscle regeneration

This stimulation can lead to undesirable side effects such as insomnia, anxiety, and cardiovascular issues, including elevated heart rate and blood pressure

Patients communicate adjustment requests to their care team through the portal and the licensed provider reviews and issues the updated prescription

This National Psoriasis Foundation primer, published in JAMA Dermatology, provides dermatologists and rheumatologists with a practical framework for understanding GLP-1 RA pharmacology, their landmark cardiovascular, metabolic, and organ-protection trial data, the emerging evidence base for psoriasis-specific benefit, and a clinical guide to agent selection, dosing, and safety monitoring in patients with psoriasis