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These systems reproduce key hallmarks of AD pathology, including A deposition, tau pathology, and glial activation

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As the largest organ of the human body and the first line of defense against the external environment, the skin can shield the internal organs from damage ( 2 Sources of ROS in the skin and initiation of oxidative stress There are two main sources of ROS in the skin: endogenous and exogenous

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References Kimura H, Takeda K, Tsuruya K et al (2010) Left ventricular mass index is an independent determinant of diastolic dysfunction in patients on chronic hemodialysis: a tissue Doppler imaging study

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Piceatannol inhibits melanogenesis by its antioxidative actions

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