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Participants were randomly assigned to oral semaglutide or a placebo, with neither side knowing which
The patients who lose the most make healthy choices most of the time
However, careful consideration must be given to the safety profile of GLP-1 RAs, particularly their gastrointestinal side effects and rare risks, such as pancreatitis and thyroid-related complications [19, 71]
In osteoarthritis, METTL3 methylates ATG7 mRNA, reducing its stability and expression, which promotes fibroblast-like synoviocyte senescence and cartilage breakdown through the autophagyGATA4 pathway
Worsening symptoms in the face of stable concentrations suggest other factors (diet changes, stress, concurrent illness) are contributing
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