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How Does Semaglutide Work
The resulting increase in intracellular NAD+ availability activates sirtuins particularly SIRT1, which regulates insulin sensitivity, gluconeogenesis, cholesterol synthesis, and fatty acid oxidation, and SIRT3, which governs mitochondrial antioxidant defences and energy metabolism
35 MetaxasC.MathisD.JegerC.HersbergerK
doi: 10.3389/fpsyt.2019.00207 41 JonesKSParkingtonDABourassaMWCeramiCKoulmanA
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