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The starting dose is typically 0.25mg , which is increased to 0.5mg after 4 weeks

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Any known temperature excursions

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In early OA, MQC dysfunction is first manifested as abnormal activation of mitochondrial dynamics imbalance, where Drp1-mediated mitochondrial fission is abnormally activated leading to mitochondrial fragmentation, accompanied by weakened Mfn1/2-mediated fusion function, directly damaging the integrity of the mitochondrial respiratory chain and triggering explosive accumulation of ROS (40, 41)