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How GLP-1 Medications Compare The honest comparison is this: GLP-1 medications produce significantly greater average weight loss than bupropion-based options, they work through a different and more direct mechanism of appetite suppression, and they have additional metabolic benefits including improvements in blood sugar, blood pressure, and cardiovascular risk that bupropion doesnt offer

After the trial period, 36% of participants on semaglutide met a composite goal of 70% timeinrange, minimal hypoglycemia and 5% weight loss, versus 0% on placebo

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Antioxidants & redox signaling 8 , 17911806, doi: 10.1089/ars.2006.8.1791 (2006)