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Patients with liver disease or those who consume three or more alcoholic drinks daily should limit intake to 2,000 mg daily or less, or consult their healthcare provider before use

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10.1001/jama.2019.11505 40 FontesA

The authors reported that intra-articular AOD-9604 injection in the rabbit osteoarthritis model produced macroscopic, histologic, and biomechanical evidence of cartilage preservation relative to untreated controls, with the combination of AOD-9604 plus hyaluronic acid yielding the most consistent chondroprotective effect [4]