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Therefore, activity of the TCA cycle is likely to influence cellular processes by mechanisms beyond just the production of ATP from the electron transport chain

Zhang W, Siraj S, Zhang R, Chen Q

Future studies combining -cell states defined by scRNA-seq and snATAC-seq with quantitative measures of SCFA, indole derivatives, or endotoxemia have the potential to reveal whether specific -cell subpopulations preferentially associate with distinct microbiota-derived signatures or display differential transcriptional responses to incretin- and SCFA-dependent interventions, thereby advancing a systems-level understanding of microbiota-cell interactions

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