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Further investigation showed that CPs first reduce the level of skin oxidation, inhibit the expression of the key transcription factor AP-1 (c-Jun and c-Fos), then activate the TGF-/Smad signaling pathway to promote collagen synthesis, inhibit the expression of MMP-1/3 to inhibit collagen degradation, and inhibit skin inflammation to alleviate skin aging in mice

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Back Lund, PK, Goodman, RH, Jacobs, JW, Habener, JF (July 1980) 'Glucagon precursors identified by immunoprecipitation of products of cell-free translation of messenger RNA', Diabetes , 29, 583-86

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Other go through the bloodstream and then they impact things like digestion, like inflammation, like blood sugar