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The risk is severe caloric restriction that drops below 800 to 1,000 calories per day, which triggers metabolic adaptation, muscle loss, nutrient deficiencies, and hormonal disruption

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The study shows they prevent new addictions by 14-25% (alcohol, opioids, cocaine, nicotine) AND reduce deaths by 50% in people with existing substance use disorders

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Endocrinology (2012) 153:578295
