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A 2,700person realworld study presented at the 2025 European Congress on Obesity showed an average 16% weightloss over 64 weeks at microdose levels of semaglutide

Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity - Diabetes, Obesity and Metabolism Effects of GLP-1 and Incretin-Based Therapies on Gastrointestinal Motor Function - Journal of Diabetes Research Once-Weekly Semaglutide in Adults with Overweight or Obesity - The New England Journal of Medicine Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report - Diabetes Care The underappreciated role of muscle in health and disease - The American Journal of Clinical Nutrition Enhanced protein intake on maintaining muscle mass, strength, and physical function in adults with overweight/obesity: A systematic review and meta-analysis - European Society for Clinical Nutrition and Metabolism Can dietary viscous fiber affect body weight independently of an energy-restrictive diet

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There are different drugs within the GLP-1 category, but semaglutide, which is a weekly injectable medication, is among the best known due to its large impact on weight and the fact that it was the first GLP-1 approved for weight loss