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The impact of metabolic activity on ER homeostasis is most evident form the association of ER stress with obesityparticularly in highly metabolically active tissues such as liver, pancreas, and adipose (Cnop, Foufelle, & Velloso, 2012)

This protective effect was primarily driven by a 30% reduction in liver decompensation events, comprising ascites, hepatic encephalopathy, variceal bleeding, and hepatorenal syndrome (IRR: 0.70, 95%CI: 0.52-0.94, P = 0.020), based on six studies comprising 877,488 participants